Endocrine Abstracts

Orlistat and Metformin have both been shown to be beneficial in the treatment of Polycystic Ovarian Syndrome (PCOS), however, because Orlistat works by decreasing the absorption of dietary lipids, there is the potential to decrease absorption of lipophilic antioxidant substances with consequent decreased protection from oxidative stress. The objective of this study was to evaluate and compare the effect of treatment with orlistat vs. metformin on oxidative stress in pat...

A 17 year old phenotypically female Middle Eastern patient presented with a short history of abdominal pain. Laparotomy and biopsy confirmed extensive mixed germ cell tumour with yolk sac elements. After referral to London, remission was achieved with 6 cycles of Bleomycin, Etoposide and Cisplatinum (alpha feta protein decreasing from 12 714 to 5 milli units per litre). Examination revealed short stature, absent pubertal development and primary amenorrhoea. She had palmar, buc...